Efek Diet Tinggi Protein, Rendah Karbohidrat, Rendah Lemak pada Tikus Wistar Jantan terhadap Perubahan Berat Badan, Kadar Glukosa dan Kolesterol

Penulis

  • Nur Upik En Masrika Hasanuddin University
  • Aryadi Arsyad
  • Ika Yustisia
  • Yulia Yusrini Djabir

DOI:

https://doi.org/10.30829/jumantik.v6i1.7891

Abstrak

One of the most popular diets today recommends a high protein- low carbohydrate diet as a weight loss strategy in obese patients. Diets high in protein appear to reduce appetite, energy intake, weight gain, and fat accumulation. The application of a high-protein diet has an impact on reducing the portion of other macronutrients, namely carbohydrates and fats. The purpose of this study was to determine the effect of a high protein, low carbohydrate and low fat (TPRKRL) diet on body health. With the focus of the analysis on changes in body weight, serum glucose and cholesterol levels in 22 male Wistar rat samples who were given the standard diet and the TPRKRL diet for 8 weeks. The results showed that there were no significant differences in the variables of body weight, serum glucose and cholesterol levels between the TPRKRL diet group and the control group (standard diet). In fact, the rats in the TPRKRL group experienced a relatively constant increase in body weight and glucose and cholesterol levels were susceptible to normal.Keywords: high protein; body weight; glucose; cholesterol

Biografi Penulis

Nur Upik En Masrika, Hasanuddin University

Biomedical Science Concentration in Physiology, Faculty of Medicine, Hasanuddin University

Referensi

Antonio, J., Ellerbroek, A., Silver, T., Orris, S., Scheiner, M., Gonzalez, A., & Peacock, C. A. (2015). A high protein diet (3.4 g/kg/d) combined with a heavy resistance training program improves body composition in healthy trained men and women - a follow-up investigation. Journal of the International Society of Sports Nutrition, 12(1), 1-9. https://doi.org/10.1186/s12970-015-0100-0

Antonio, J., Ellerbroek, A., Silver, T., Vargas, L., & Peacock, C. (2016). The effects of a high protein diet on indices of health and body composition - a crossover trial in resistance-trained men. Journal of the International Society of Sports Nutrition, 13(1), 1-7. https://doi.org/10.1186/s12970-016-0114-2

Antonio, P., Lorenzo, C., & A, G. K. A. (2011). Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees. Nutrition Journal, 10, 112. http://www.ncbi.nlm.nih.gov/pubmed/21992535

Aparicio, V. A., Nebot, E., García-del Moral, R., Machado-Vílchez, M., Porres, J. M., Sánchez, C., & Aranda, P. (2013). High-protein diets and renal status in rats. Nutricion Hospitalaria, 28(1), 232-237. https://doi.org/10.3305/nh.2013.28.1.6165

Depkes. (2013). Riset Kesehatan Dasar (Riskesdas). http://www.depkes.go.id/resources/download/general/Hasil Riskesdas 2013.pdf

Hall, J. E. (2016). Guyton dan Hall Buku Ajar Fisiologi Kedokteran Edisi 12 (E. I, I. Ilyas, M. D. Widjajakusumah, & A. Tanzil (eds.)). Saunders Elsevier.

Hernandez Bautista, R. J., Mahmoud, A. M., Konigsberg, M., & Lopez Diaz Guerrero, N. E. (2019). Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants. Biomedicine and Pharmacotherapy, 111(October 2018), 503-516. https://doi.org/10.1016/j.biopha.2018.12.108

Hu, T., Mills, K. T., Yao, L., Demanelis, K., Eloustaz, M., Yancy, W. S., Kelly, T. N., He, J., & Bazzano, L. A. (2012). Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: A meta-analysis of randomized controlled clinical trials. American Journal of Epidemiology, 176(SUPPL. 7). https://doi.org/10.1093/aje/kws264

Huntari, H., Irfannuddin, I., & Murti, K. (2018). Pengaruh diet ketogenik terhadap ekspresi Ki-67, Caspase-3, dan MDA pada jaringan hati. Jambi Medical Journal Jurnal Kedokteran Dan Kesehatan, 6(2)(November), 185-194. https://doi.org/10.22437/jmj.v6i2.5973

Jean, C., Rome, S., Mathé, V., Huneau, J.-F., Aattouri, N., Fromentin, G., Achagiotis, C. L., & Tomé, D. (2001). Metabolic Evidence for Adaptation to a High Protein Diet in Rats. The Journal of Nutrition, 131(1), 91-98. https://doi.org/10.1093/jn/131.1.91

Luscombe, N. D., Clifton, P. M., Noakes, M., Farnsworth, E., & Wittert, G. (2003). Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects. International Journal of Obesity, 27(5), 582-590. https://doi.org/10.1038/sj.ijo.0802270

Paoli, A., Rubini, A., Volek, J. S., & Grimaldi, K. A. (2013). Beyond weight loss: A review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition, 67(8), 789-796. https://doi.org/10.1038/ejcn.2013.116

Pesta, D. H., & Samuel, V. T. (2014). A high-protein diet for reducing body fat: Mechanisms and possible caveats. Nutrition and Metabolism, 11(1), 1-8. https://doi.org/10.1186/1743-7075-11-53

Schutz, Y. (2011). Protein turnover, ureagenesis and gluconeogenesis. International Journal for Vitamin and Nutrition Research, 81(23), 101-107. https://doi.org/10.1024/0300-9831/a000064

Schwingshackl, L., & Hoffmann, G. (2014). Comparison of High vs . Normal / Low Protein Diets on Renal Function in Subjects without Chronic Kidney Disease : A Systematic Review and Meta-Analysis. 9(5). https://doi.org/10.1371/journal.pone.0097656

Soenen, S., Martens, E. A. P., Hochstenbach-Waelen, A., Lemmens, S. G. T., & Westerterp-Plantenga, M. S. (2013). Normal Protein Intake Is Required for Body Weight Loss and Weight Maintenance, and Elevated Protein Intake for Additional Preservation of Resting Energy Expenditure and Fat Free Mass. The Journal of Nutrition, 143(5), 591-596. https://doi.org/10.3945/jn.112.167593

Unduhan

Diterbitkan

2021-02-08

Terbitan

Vol 6 No 1 (2021)

Bagian

Articles

Lisensi

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-SA that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.